ingredientObeticholic Acid 5mg
substitutesObeticholic Acid 5mg
Shipping classRoom Temperature
Medicine Overview by Anukar Pharmacy
( OcaNat 5mg 100 Tablet )
TreatmentOcaNat is reserved for the treatment of initial biliary cholangitis in combination with ursodeoxycholic acid in grown-ups with a deficient response to ursodeoxycholic acid, or as a solitary treatment in grown-ups not able to endure ursodeoxycholic acid.
Side EffectsPain in the middle part of the throat (oropharyngeal), Severe itching of the skin (pruritus), Abdominal pain and discomfort, Generalized weakness, Joint pain (arthralgia), Fatigue, Dizziness, Constipation, Headache, Mild fever
Method of UseThe tablet should be taken orally with or without food.
How WorksObeticholic acid is a selective and potent agonist for the farnesoid X receptor (FXR), a nuclear receptor expressed at high levels in the liver and intestine. FXR is thought to be a key regulator of bile acid, inflammatory, fibrotic, and metabolic pathways. FXR activation decreases the intracellular hepatocyte concentrations of bile acids by suppressing de novo synthesis from cholesterol, as well as, by increasing transport of bile acids out of the hepatocytes. These mechanisms limit the overall size of the circulating bile acid pool while promoting choleresis, thus reducing hepatic exposure to bile acids.
More Info by Anukar Pharmacy
( OcaNat 5mg 100 Tablet )
Suggestions
- International normalised ratio (INR) is decreased following co-administration of warfarin and obeticholic acid. INR should be monitored and the dose of warfarin adjusted, if needed, to maintain the target INR range when co-administering obeticholic acid and warfarin.
- Obeticholic acid may increase the exposure to concomitant medicinal products that are CYP1A2 substrates. Therapeutic monitoring of CYP1A2 substrates with narrow therapeutic index (e.g. theophylline and tizanidine) is recommended.
- Bile acid binding resins such as cholestyramine, colestipol, or colesevelam adsorb and reduce bile acid absorption and may reduce efficacy of obeticholic acid. When concomitant bile acid binding resins are administered, obeticholic acid should be taken at least 4-6 hours before or 4-6 hours after taking a bile acid binding resin, or at as great an interval as possible.
Warning by Anukar Pharmacy
( OcaNat 5mg 100 Tablet )
Special precautions for ( OcaNat 5mg 30 Tablet ) Heads up
| aspect | highlight | details |
|---|---|---|
Alcohol
|
There are no sufficient data. Please consult your doctor. | |
Pregnancy
|
caution | There are no data on the use of obeticholic acid in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity . As a precautionary measure, it is preferable to avoid the use of obeticholic acid during pregnancy. |
Lactation
|
WEIGH RISKS VS BENEFITS | It is unknown whether obeticholic acid is excreted in human milk. Based on animal studies and intended pharmacology, obeticholic acid is not expected to interfere with breast-feeding or the growth or development of a breast-fed child. A decision should be made whether to discontinue breast-feeding or to discontinue/abstain from obeticholic acid therapy taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman. |
Driving
|
safe | Obeticholic acid has no or negligible influence on the ability to drive and use machines. |
Kidney
|
caution | Limited data exists in patients with mild and moderate renal impairment and no data exists in severe renal impairment. No dose adjustment is required for patients with renal impairment. |
Liver
|
safe | Limited data exists in elderly patients. No dose adjustment is required for elderly patients. |
Suggestion by Anukar Pharmacy on missing a dose
( OcaNat 5mg 100 Tablet )
If you miss a dose, please take the next dose as soon as you remember.
Disclaimer
The information of Anukar Pharmacy is for reference purpose only, and Anukar Pharmacy or Anukar Pharmacy or Anukar Pharmacy is not intended to be a replacement of professional medical advice, diagnosis, or treatment. Anukar Pharmacy suggest to ask the advice of a physician or any qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of anything you have learned from Anukar Pharmacy.
| 药名 | 奥贝胆酸 |
| 厂家 | Natco |
| 成分 | Nintedanib 150mg |
| 说明 |
奥贝胆酸
奥贝胆酸
奥贝胆酸
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* 以上中文信息由印度阿努卡药房收集的OcaNat 5mg Tablet, Natco（奥贝胆酸）中文网络信息和软件翻译获得，阿努卡药房认为OcaNat 5mg Tablet, Intercept（奥贝胆酸）中文产品介绍信息存在与OcaNat 5mg 100 Tablet, Intercept（奥贝胆酸）实际数据不一致的可能。阿努卡药房请用户把OcaNat 5mg Tablet, Intercept（奥贝胆酸）页面数据作为参考。印度阿努卡药房建议用户在实际使用OcaNat 5mg Tablet, Intercept（奥贝胆酸）数据或者信息时，以OcaNat 5mg Tablet, Intercept（奥贝胆酸）制造商公开发布的OcaNat 5mg Tablet, Intercept（奥贝胆酸）商品信息为参考。使用方法，以用户医生建议使用OcaNat 5mg 100 Tablet, Intercept（奥贝胆酸）决定为参考。用户任何关于OcaNat 5mg Tablet, Intercept（奥贝胆酸）的建议，可以通知印度阿努卡药房，或通知阿努卡在线客服人员。谢谢
