ingredientAtezolizumab
substitutesAtezolizumab 1200mg 1s
Shipping classCold chain shipment
Medicine Overview by Anukar Pharmacy
( Tecentriq 1200mg 1s Injection )
TreatmentTECENTRIQ is indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) who have disease progression during or following platinum-containing chemotherapy.
Side EffectsImmune-Mediated Pneumonitis, Immune-Mediated Hepatitis, Immune-Mediated Colitis, Immune-Mediated Endocrinopathies, Other Immune-Mediated Adverse Reactions, Infections, Infusion-Related Reactions
Method of UseThe recommended dosage of TECENTRIQ is 1200 mg as an intravenous infusion over 60 minutes every 3 weeks until disease progression or unacceptable toxicity. If the first infusion is tolerated, all subsequent infusions may be delivered over 30 minutes.
How WorksMonoclonal antibody to programmed cell death ligand-1 protein (PDL1); binding PDL1 blocks the interaction between PDL-1 and its ligands. PDL1 is expressed on the surface of activated T cells under normal conditions; binding PDL1 inhibits immune activation and reduces T-cell cytotoxic activity when bound. This negative feedback loop is essential for maintaining normal immune responses and limits T-cell activity to protect normal cells during chronic inflammation. Tumor cells may circumvent T-cell?Cmediated cytotoxicity by expressing PDL1 on the tumor itself or on tumor-infiltrating immune cells, resulting in the inhibition of immune-mediated killing of tumor cells.
More Info by Anukar Pharmacy
( Tecentriq 1200mg 1s Injection )
Suggestions
- Immune-related myasthenic syndrome/myasthenia gravis, Guillain Barr??, or meningoencephalitis reported; permanently discontinue for any grade.
- Monitor for clinical signs and symptoms of meningitis or encephalitis; permanently discontinue treatment for any grade of meningitis or encephalitis; treat with IV steroids (1-2 mg/kg/day methylprednisolone or equivalent) and convert to oral steroids (prednisone 60 mg/day or equivalent) once patient improves; when symptoms improve to Grade ??1, taper steroids over ??1 month.
- Monitor for symptoms of motor and sensory neuropathy; permanently discontinue treatment for any grade of myasthenic syndrome/myasthenia gravis or Guillain-Barr?? syndrome; consider initiation of systemic corticosteroids at a dose of 1-2 mg/kg/day prednisone.
- Symptomatic pancreatitis without an alternative etiology occurred in 0.1% of patients across clinical trials; monitor for signs and symptoms of acute pancreatitis.
- Monitor for signs and symptoms of myocarditis.
- Thyroid disorders may occur; monitor thyroid function prior to and periodically during treatment; initiate hormone replacement therapy or medical management of hyperthyroidism as clinically indicated; continue therapy for hypothyroidism and interrupt for hyperthyroidism based on severity.
- Adrenal insufficiency may occur; monitor patients for clinical signs and symptoms of adrenal insufficiency; for Grade 2 or higher adrenal insufficiency, initiate prednisone 1-2 mg/kg/day or equivalents, followed by a taper and hormone replacement as clinically indicated; interrupt treatment based on severity.
- Type 1 diabetes mellitus reported; monitor patients for hyperglycemia or other signs and symptoms of diabetes; initiate treatment with insulin as clinically indicated; interrupt treatment based on severity.
- Hypophysitis/hypopituitarism may occur; for Grade 2 or higher hypophysitis, initiate prednisone 1-2 mg/kg/day or equivalents, followed by a taper and hormone replacement therapy as clinically indicated
Warning by Anukar Pharmacy
( Tecentriq 1200mg 1s Injection )
Special precautions for ( Tecentriq 1200mg 1s Injection ) Heads up
| aspect | highlight | details |
|---|---|---|
Alcohol
|
There is no significant data. Please consult your doctor. | |
Pregnancy
|
caution | Based on its mechanism of action, TECENTRIQ can cause fetal harm when administered to a pregnant woman. There are no available data on the use of TECENTRIQ in pregnant women. |
Lactation
|
There is no information regarding the presence of atezolizumab in human milk, the effects on the breastfed infant, or the effects on milk production. | |
Driving
|
There is no significant data. Please consult your doctor. | |
Kidney
|
Monitor the renal values. | |
Liver
|
May cause liver test abnormalities and immune-mediated hepatitis; fatal cases reported; monitor for signs and symptoms of hepatitis, during and after discontinuation of therapy, including clinical chemistry monitoring; administer corticosteroids, prednisone 1?C2 mg/kg/day or equivalents, followed by a taper for Grade 2 or higher elevations of ALT, AST and/or total bilirubin. |
Suggestion by Anukar Pharmacy on missing a dose
( Tecentriq 1200mg 1s Injection )
For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule.
Disclaimer
The information of Anukar Pharmacy is for reference purpose only, and Anukar Pharmacy or Anukar Pharmacy or Anukar Pharmacy is not intended to be a replacement of professional medical advice, diagnosis, or treatment. Anukar Pharmacy suggest to ask the advice of a physician or any qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of anything you have learned from Anukar Pharmacy.
| 药名 | 阿特珠单抗, 特善奇, 泰圣奇 |
| 厂家 | 罗氏 |
| 成分 | Altzolizumab,阿特珠单抗 |
| 说明 |
特善奇
Tecentriq，在与贝伐单抗，紫杉醇和卡铂组合，一线治疗转移性非鳞状非小细胞肺癌（NSCLC NSQ），无EGFR或ALK基因组肿瘤异常突变。
治疗作用：小细胞肺癌、乳腺癌、非小细胞肺癌、尿路上皮癌
|
* 以上中文信息由印度阿努卡药房收集的Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）中文网络信息和软件翻译获得，阿努卡药房认为Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）中文产品介绍信息存在与Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）实际数据不一致的可能。阿努卡药房请用户把Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）页面数据作为参考。印度阿努卡药房建议用户在实际使用Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）数据或者信息时，以Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）制造商公开发布的Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）商品信息为参考。使用方法，以用户医生建议使用Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）决定为参考。用户任何关于Tecentriq 1200mg 1s Injection, Roche（阿特珠单抗, 特善奇, 泰圣奇）的建议，可以通知印度阿努卡药房，或通知阿努卡在线客服人员。谢谢
